rrx 001 Search Results


selleck 153 chemicals  (Selleck Chemicals)
94
Selleck Chemicals selleck 153 chemicals
Selleck 153 Chemicals, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pm41495462-38-6-6?v=Selleck+Chemicals
Average 94 stars, based on 1 article reviews
selleck 153 chemicals - by Bioz Stars, 2026-07
94/100 stars
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rrx-001  (EpicentRx)
90
EpicentRx rrx-001
Rrx 001, supplied by EpicentRx, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pmc05918142-80-8-2?v=EpicentRx
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (RadioRx Inc)
90
RadioRx Inc rrx-001
Rrx 001, supplied by RadioRx Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pmc03384267-235-28-57?v=RadioRx+Inc
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (BioMimetic Therapeutics)
90
BioMimetic Therapeutics rrx-001
Rrx 001, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pm40055311-817-26-44?v=BioMimetic+Therapeutics
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001 treatment  (GraphPad Software Inc)
90
GraphPad Software Inc rrx-001 treatment
(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from <t>RRx-001</t> and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.
Rrx 001 Treatment, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/bio_rxiv__2024__08__12__607591-198-5-12?v=GraphPad+Software+Inc
Average 90 stars, based on 1 article reviews
rrx-001 treatment - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (NanoCarrier Co)
90
NanoCarrier Co rrx-001
(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from <t>RRx-001</t> and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.
Rrx 001, supplied by NanoCarrier Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pmc10640620__41467_2023_42972_MOESM2_ESM-404-5-8?v=NanoCarrier+Co
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (Verlag GmbH)
90
Verlag GmbH rrx-001
(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from <t>RRx-001</t> and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.
Rrx 001, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pm32468692-26-18-11?v=Verlag+GmbH
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (Informa UK Limited)
90
Informa UK Limited rrx-001
(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from <t>RRx-001</t> and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.
Rrx 001, supplied by Informa UK Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/pm33306414-2-49-20?v=Informa+UK+Limited
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx-001  (Coldstream Laboratories)
90
Coldstream Laboratories rrx-001
(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from <t>RRx-001</t> and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.
Rrx 001, supplied by Coldstream Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rrx+001/10__1016_slash_s1470___2045_ascii40_15_ascii41_00089___3-44-0-13?v=Coldstream+Laboratories
Average 90 stars, based on 1 article reviews
rrx-001 - by Bioz Stars, 2026-07
90/100 stars
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rrx 001  (Cayman Chemical)
N/A
RRX 001
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rrx-001  (MedChemExpress)
N/A
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity. RRx-001 is a dual small molecule checkpoint
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rrx-001  (Biosynth Carbosynth)
N/A
RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity.. Epigenetic modulator; hypoxia-activated nitric oxide donor; radiosensitizer.
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Image Search Results


(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from RRx-001 and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.

Journal: bioRxiv

Article Title: Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

doi: 10.1101/2024.08.12.607591

Figure Lengend Snippet: (A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 10 and 14 from RRx-001 and vehicle treated mice. (C) Lesion bioluminescent signal of RRx-001 and vehicle treated mice with endometriosis; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. (F) Mechanical hyperalgesia measured using von Frey filaments applied to the abdomen and (G) hind paw (F and G plotted as an average of 3 measurements taken over days 11-13 post-endometriosis induction; statistical analyses performed using a Mann-Whitney test). * p < 0.05, ** p < 0.01, **** p < 0.001.

Article Snippet: Animals were randomised to either RRx-001 treatment or control group using the GraphPad QuickCalcs online tool ( https://www.graphpad.com/quickcalcs/randomize1/ ).

Techniques: MANN-WHITNEY

(A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 14 and 21 from RRx-001 and vehicle treated mice. (C) Bioluminescent signal of RRx-001 and vehicle treated mice; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. * p < 0.05, ** p < 0.01.

Journal: bioRxiv

Article Title: Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

doi: 10.1101/2024.08.12.607591

Figure Lengend Snippet: (A) Schematic of experimental design. (B) Representative frontal images from days 3, 7, 14 and 21 from RRx-001 and vehicle treated mice. (C) Bioluminescent signal of RRx-001 and vehicle treated mice; statistical analysis performed using a two-way ANOVA with Bonferroni post hoc. (D) Number of lesions and (E) size of lesions recovered from RRx-001 and vehicle mice; statistical analyses performed using a Mann-Whitney test. * p < 0.05, ** p < 0.01.

Article Snippet: Animals were randomised to either RRx-001 treatment or control group using the GraphPad QuickCalcs online tool ( https://www.graphpad.com/quickcalcs/randomize1/ ).

Techniques: MANN-WHITNEY

(A) Schematic of experimental design. (B) UMAP visualisation based on a weighted combination of RNA and ATAC data from peritoneal macrophages isolated from vehicle treated endometriosis mice, RRx-001 treated endometriosis mice and sham mice. Inset is UMAP projection split by sample ID. (C) Feature plots of Ptprc (Cd45), Itgam (Cd11b), Adgre1 (F4/80) and H2-Ab1 (MhcII) expression levels. (D) Proportion of each cluster occupied by each sample. (E) Dot plot of featured genes. (F) Chromatin accessibility, gene expression data and peak-gene links for Ccr2 expression in selected macrophage populations. (G) Volcano plot of up- and down-regulated DEGs of pro-resolving LpM compared to pro-disease LpM. (H) Transcription factor footprinting of Cebpb and Gata6 in pro-resolving LpM, pro-disease LpM and prototypical LpM populations. (I) DNA sequence motif enrichment analysis of ATAC data in peritoneal macrophages derived from RRx-001 treated endometriosis mice.

Journal: bioRxiv

Article Title: Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

doi: 10.1101/2024.08.12.607591

Figure Lengend Snippet: (A) Schematic of experimental design. (B) UMAP visualisation based on a weighted combination of RNA and ATAC data from peritoneal macrophages isolated from vehicle treated endometriosis mice, RRx-001 treated endometriosis mice and sham mice. Inset is UMAP projection split by sample ID. (C) Feature plots of Ptprc (Cd45), Itgam (Cd11b), Adgre1 (F4/80) and H2-Ab1 (MhcII) expression levels. (D) Proportion of each cluster occupied by each sample. (E) Dot plot of featured genes. (F) Chromatin accessibility, gene expression data and peak-gene links for Ccr2 expression in selected macrophage populations. (G) Volcano plot of up- and down-regulated DEGs of pro-resolving LpM compared to pro-disease LpM. (H) Transcription factor footprinting of Cebpb and Gata6 in pro-resolving LpM, pro-disease LpM and prototypical LpM populations. (I) DNA sequence motif enrichment analysis of ATAC data in peritoneal macrophages derived from RRx-001 treated endometriosis mice.

Article Snippet: Animals were randomised to either RRx-001 treatment or control group using the GraphPad QuickCalcs online tool ( https://www.graphpad.com/quickcalcs/randomize1/ ).

Techniques: Isolation, Expressing, Footprinting, Sequencing, Derivative Assay

(A) Slingshot fitted trajectories and principal curves. (B) Pseudotime ordering of inferred lineages (left) with multinomial logistic regression analysis of pseudo-temporal sample imbalance (right). (C) Scatter plot of aggregate (pseudobulk) expression of LpM and SpM populations from RRx-001 and vehicle treated mice (Pearson correlation reported). (D) ClusterProfiler gene set enrichment analysis using GO terms showing the top 5 terms in the LpM and SpM of RRx-001 treated mice with induced endometriosis. (E) ClusterProfiler gene set enrichment analysis using KEGG pathways showing the top 5 pathways in the LpM and SpM of RRx-001 treated mice with induced endometriosis. (F) Violin plots of Sirpα expression in RNA-seq data and the gene activity matrix derived from ATAC-seq data.

Journal: bioRxiv

Article Title: Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

doi: 10.1101/2024.08.12.607591

Figure Lengend Snippet: (A) Slingshot fitted trajectories and principal curves. (B) Pseudotime ordering of inferred lineages (left) with multinomial logistic regression analysis of pseudo-temporal sample imbalance (right). (C) Scatter plot of aggregate (pseudobulk) expression of LpM and SpM populations from RRx-001 and vehicle treated mice (Pearson correlation reported). (D) ClusterProfiler gene set enrichment analysis using GO terms showing the top 5 terms in the LpM and SpM of RRx-001 treated mice with induced endometriosis. (E) ClusterProfiler gene set enrichment analysis using KEGG pathways showing the top 5 pathways in the LpM and SpM of RRx-001 treated mice with induced endometriosis. (F) Violin plots of Sirpα expression in RNA-seq data and the gene activity matrix derived from ATAC-seq data.

Article Snippet: Animals were randomised to either RRx-001 treatment or control group using the GraphPad QuickCalcs online tool ( https://www.graphpad.com/quickcalcs/randomize1/ ).

Techniques: Expressing, RNA Sequencing Assay, Activity Assay, Derivative Assay

(A) Length of oestrous cycle and (B) days spent within each stage; n=3 vehicle, n=4 RRx-001; statistical analyses performed using Student’s t test and two-way ANOVA with Bonferroni post hoc. (C) Time to detection of seminal plug; n=15 RRx-001, n=15 vehicle; statistical analysis performed using a Student’s t test. (D) Embryonic number and (E) average weight at E10.5; n=5 RRx-001, n=8 vehicle; statistical analyses performed using a Student’s t test. (F) Median fluorescence intensity of SIRPα, CD206 (pro-repair) and CD40 (pro-inflammatory) in Hofbauer cells pooled from 3 placentas per mouse at embryonic day 15.5; n=3 RRx-001, n=4 vehicle, statistical analysis performed using Student’s t test. (G) Gestational length of pregnancy, (H) number of pups born to each mouse, (I) sex ratio of litter and (J) average litter weights from postnatal day 7 to postnatal day 28; n=4 RRx-001, n=3 vehicle; statistical analyses performed using Student’s t tests. No statistical significance reached p < 0.05.

Journal: bioRxiv

Article Title: Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

doi: 10.1101/2024.08.12.607591

Figure Lengend Snippet: (A) Length of oestrous cycle and (B) days spent within each stage; n=3 vehicle, n=4 RRx-001; statistical analyses performed using Student’s t test and two-way ANOVA with Bonferroni post hoc. (C) Time to detection of seminal plug; n=15 RRx-001, n=15 vehicle; statistical analysis performed using a Student’s t test. (D) Embryonic number and (E) average weight at E10.5; n=5 RRx-001, n=8 vehicle; statistical analyses performed using a Student’s t test. (F) Median fluorescence intensity of SIRPα, CD206 (pro-repair) and CD40 (pro-inflammatory) in Hofbauer cells pooled from 3 placentas per mouse at embryonic day 15.5; n=3 RRx-001, n=4 vehicle, statistical analysis performed using Student’s t test. (G) Gestational length of pregnancy, (H) number of pups born to each mouse, (I) sex ratio of litter and (J) average litter weights from postnatal day 7 to postnatal day 28; n=4 RRx-001, n=3 vehicle; statistical analyses performed using Student’s t tests. No statistical significance reached p < 0.05.

Article Snippet: Animals were randomised to either RRx-001 treatment or control group using the GraphPad QuickCalcs online tool ( https://www.graphpad.com/quickcalcs/randomize1/ ).

Techniques: Fluorescence